BDBM50005835 (3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methylmethanesulfonamide::1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide::1-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}-N-methylmethanesulfonamide::3-(2-(dimethylamino)ethyl)-N-methyl-1H-indole-5-methanesulfonamide::3-[2-(dimethylamino)ethyl]-N-methylindole-5-methanesulfonamide::CHEMBL128::SUMATRIPTAN::Sumatran::Sumax

SMILES CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

InChI Key InChIKey=KQKPFRSPSRPDEB-UHFFFAOYSA-N

Data  115 KI  52 IC50  4 Kd  15 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 39 hits for monomerid = 50005835   

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  1.20nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  1.99nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  5.5nMAssay Description:Binding affinity was measured on 5-hydroxytryptamine 1D receptor beta in CHO cells transfected with human 5-HT1D beta gene labeled with [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Gorilla gorilla gorilla)
Pharmacia & Upjohn

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  6.40nMAssay Description:The compound was tested for CNS binding affinity towards 5-hydroxytryptamine 1B receptor from cloned gorilla membranes expressed in cultured HEK 293 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity of the compound was evaluated at the cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  7.76nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  9.10nMAssay Description:Displacement of [3H]5-hydroxytryptamine from human cloned 5HT1B receptor expressed in CHOK1 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  9.33nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  9.60nMAssay Description:In vitro receptor binding affinity for cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  10nMAssay Description:Binding affinity for recombinant human 5-hydroxytryptamine 1D receptor beta was determined using [3H]-5-HT as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  11.0nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  19nMAssay Description:In vitro binding affinity was determined towards cloned human 5-hydroxytryptamine 1B receptor using [3H]-5-CT radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  22nMAssay Description:Compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor beta expressed in CHO-K1 cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Medical College Of Virginia/Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  23nMAssay Description:Binding affinity was measured on 5-hydroxytryptamine 1B receptor in rat striatum labeled with [3H]-5-HTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  23nMAssay Description:The compound was tested for binding affinity against cloned human 5-hydroxytryptamine 1D receptor betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  23.1nMAssay Description:Ability to inhibit the forskolin-stimulated c-AMP formation mediated by human 5-hydroxytryptamine 1B receptor in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  24nMAssay Description:Compound was tested for intrinsic efficacy against human 5-hydroxytryptamine 1D receptor beta measured as the reduction of forskolin-stimulated cAMP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  25.1nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  28nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  36nMAssay Description:Binding affinity for human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Medical College Of Virginia/Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  44.7nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  48nMAssay Description:Binding affinity towards cloned human 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  60nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  61.6nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Medical College Of Virginia/Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  468nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Medical College Of Virginia/Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataKi:  468nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  0.501nMAssay Description:Binding affinity in CHO-K1 cells transfected with human recombinant 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Rattus norvegicus (Rat))
Medical College Of Virginia/Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  110nMAssay Description:5-HT1D binding assays (agonist radioligand)were performed using bovine caudate membranes according to the methods of Heuring and Peroutka (J. Neurosc...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  77nMAssay Description:Inhibition of forskolin-stimulated c-AMP formation by human 5-hydroxytryptamine 1B receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  27nMAssay Description:Compound was evaluated for the affinity at 5-hydroxytryptamine 1B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  16nMAssay Description:Binding affinity to human cloned 5-hydroxytryptamine 1B receptor in CHO cells by [3H]-5-HT binding displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  16nMAssay Description:Displacement of [3H]-5-HT from human 5-hydroxytryptamine 1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]-5-HT binding from the cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  11nMAssay Description:Displacement of [3H]-5-HT binding from cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataIC50:  10nMAssay Description:Binding affinity at cloned human 5-hydroxytryptamine 1B receptor stably expressed in CHO cells by [3H]-5-HT displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP Ki Database
LigandPNGBDBM50005835((3-[2-(dimethylamino)ethyl]-1H-indol-5-yl)-N-methy...)
Affinity DataEC50:  38nMAssay Description:Effective concentration of the compound determined by measuring inhibition of forskolin-stimulated c-AMP formation at 5-hydroxytryptamine 1B receptor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank